Post by The One on Apr 13, 2009 12:32:39 GMT -5
Dextro-Cyclodized™ Delivery Technology By All American EFX
What Is It?
A Dextro-Cyclodized™ material is one that has been specifically modified using our proprietary pharmaceutical-level delivery technology to increase its ability to penetrate body tissues and release biologically active compounds under specific conditions.
This complex procedure involves processing a target organic compound (or “guest’ molecule) with cycloamylose (a cyclic oligosaccharide created from starch) to form what is known in chemistry as an “Inclusion Compound”. Cycloamylose is a water-soluble, doughnut-shaped molecule that possesses a ‘water-like’ outer surface and ‘oil-like’ inner surface.Certain organic compounds have an affinity for the inner surface of cycloamylose molecules, while others do not. Consequently, not all compounds can be used with this technology, which is why tremendous expertise is necessary to utilize it properly.
More simply put, cycloamylose is able to form a host-guest complex with hydrophobic (molecules given the unique nature imparted by their structure. Therefore, the Dextro-Cyclodizing™ process involves taking suitable organic compound molecules and “hosting” them inside cycloamylose molecules.
Ironically, the very thing that the Dextro-Cyclodizing™ process is designed to protect a compound from is also the key mechanism in the body that activates it: a change in pH. As the Dextro-Cyclodized™ complex is introduced to the highly acidic environment of the stomach and duodenum, the inclusion complex degrades and releases the active compound into the bloodstream for absorption.
Our process is most appropriate for materials that are naturally hydrophobic (not water-soluble). It is a highly effective and powerful delivery system in these cases because the treatment process greatly modifies the physical and chemical properties of the guest molecule, especially regarding water solublity. The soluability of a compound is an important charactistic for absorption because those that aren’t are, many times, hard for the body to absorb. Therefore, increasing soluability, in many cases, can increase overall potency and bioavalibilty.
What Are The Key Benefits?
*Improvement of the physicochemical characteristics of the hosted organic compound
*Improvement of shelf life (Improved stability to heat, light, oxygen)
*Improved homogeneity and content uniformity in finished product
*Improved absorption and a reduction of the recommended dose due
*Protection from the stomach and strong acids
*Enhancement of bioavailability of poorly soluble and absorbable organics
Can Anyone Do This?
In one word: No! This is an extremely complex process requiring specialized equipment, educated personal, time, and a substantial investment. In fact, the investment alone required to perform this process is the main reason why most companies would not attempt to utilize this process. Besides the added cost, other companies also do not have the technology, staff or equipment to employ this technology properly. Some have tried to develop similar delivery systems in the past. However, they did nothing more than blend a chosen compound with a cycloamylose-like material. obviously this will not work. Finally, our process is not only proprietary; it is exclusive to All American EFX.
Copycats beware! When you start seeing products appearing that claim to be “exactly” like ours, with the same delivery technology and much cheaper (and I guarantee you will), you’ll already know they’re nothing more than a cheap knockoff.
What Is It?
A Dextro-Cyclodized™ material is one that has been specifically modified using our proprietary pharmaceutical-level delivery technology to increase its ability to penetrate body tissues and release biologically active compounds under specific conditions.
This complex procedure involves processing a target organic compound (or “guest’ molecule) with cycloamylose (a cyclic oligosaccharide created from starch) to form what is known in chemistry as an “Inclusion Compound”. Cycloamylose is a water-soluble, doughnut-shaped molecule that possesses a ‘water-like’ outer surface and ‘oil-like’ inner surface.Certain organic compounds have an affinity for the inner surface of cycloamylose molecules, while others do not. Consequently, not all compounds can be used with this technology, which is why tremendous expertise is necessary to utilize it properly.
More simply put, cycloamylose is able to form a host-guest complex with hydrophobic (molecules given the unique nature imparted by their structure. Therefore, the Dextro-Cyclodizing™ process involves taking suitable organic compound molecules and “hosting” them inside cycloamylose molecules.
Ironically, the very thing that the Dextro-Cyclodizing™ process is designed to protect a compound from is also the key mechanism in the body that activates it: a change in pH. As the Dextro-Cyclodized™ complex is introduced to the highly acidic environment of the stomach and duodenum, the inclusion complex degrades and releases the active compound into the bloodstream for absorption.
Our process is most appropriate for materials that are naturally hydrophobic (not water-soluble). It is a highly effective and powerful delivery system in these cases because the treatment process greatly modifies the physical and chemical properties of the guest molecule, especially regarding water solublity. The soluability of a compound is an important charactistic for absorption because those that aren’t are, many times, hard for the body to absorb. Therefore, increasing soluability, in many cases, can increase overall potency and bioavalibilty.
What Are The Key Benefits?
*Improvement of the physicochemical characteristics of the hosted organic compound
*Improvement of shelf life (Improved stability to heat, light, oxygen)
*Improved homogeneity and content uniformity in finished product
*Improved absorption and a reduction of the recommended dose due
*Protection from the stomach and strong acids
*Enhancement of bioavailability of poorly soluble and absorbable organics
Can Anyone Do This?
In one word: No! This is an extremely complex process requiring specialized equipment, educated personal, time, and a substantial investment. In fact, the investment alone required to perform this process is the main reason why most companies would not attempt to utilize this process. Besides the added cost, other companies also do not have the technology, staff or equipment to employ this technology properly. Some have tried to develop similar delivery systems in the past. However, they did nothing more than blend a chosen compound with a cycloamylose-like material. obviously this will not work. Finally, our process is not only proprietary; it is exclusive to All American EFX.
Copycats beware! When you start seeing products appearing that claim to be “exactly” like ours, with the same delivery technology and much cheaper (and I guarantee you will), you’ll already know they’re nothing more than a cheap knockoff.
